This document is one of a series of six national guidance documents, rapidly developed by the CRISM network at the request of the Government of Canada. Collectively, the six documents address urgent needs of people who use substances, service providers, and decision makers in relation to the COVID‑19 pandemic. The purpose of this guidance document is to support organizations operating new or existing shelter settings to provide evidence-informed care for people who use substances during the COVID‑19 pandemic in Canada.